Simultaneous Tumor and Stroma Targeting by Oncolytic Viruses

Current cancer therapeutics often insufficiently eradicate malignant cells due to the surrounding dense tumor stroma.This multi-componential tissue consists of mainly cancer-associated fibroblasts, the (compact) extracellular matrix, tumor vasculature, and tumor-associated macrophages, which all exert crucial roles in maintaining a pro-tumoral nich

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Functional characterization and evaluation of in vitro protective efficacy of murine monoclonal antibodies BURK24 and BURK37 against Burkholderia pseudomallei.

Burkholderia pseudomallei, the causative agent of melioidosis has been recognized by CDC as a category B select agent.Although substantial efforts have been made for development of vaccine molecules against the pathogen, significant hurdles still remain.With no licensed vaccines available and high relapse rate of the disease, there is a pressing ne

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