Current cancer therapeutics often insufficiently eradicate malignant cells due to the surrounding dense tumor stroma.This multi-componential tissue consists of mainly cancer-associated fibroblasts, the (compact) extracellular matrix, tumor vasculature, and tumor-associated macrophages, which all exert crucial roles in maintaining a pro-tumoral nich
Functional characterization and evaluation of in vitro protective efficacy of murine monoclonal antibodies BURK24 and BURK37 against Burkholderia pseudomallei.
Burkholderia pseudomallei, the causative agent of melioidosis has been recognized by CDC as a category B select agent.Although substantial efforts have been made for development of vaccine molecules against the pathogen, significant hurdles still remain.With no licensed vaccines available and high relapse rate of the disease, there is a pressing ne
Magnetic resonance imaging of uterovaginal lesions associated with female infertility
Objective: To study the mandatory indications and accuracy of magnetic resonance (MR) imaging for the diagnosis of uterovaginal lesions associated with female infertility.Design: Prospective cross sectional study.Main outcome measures: Indications and accuracy of MR imaging for the diagnosis of uterovaginal lesions.Materials and methods: 423 infert
Emotional competencies as a factor in maintaining the mental health of medical workers
Aim.To study the protective role of emotional competencies (ECs) in maintaining the mental health of medical workers.Material and methods.The sample consisted of 170 medical workers.Methods for assessing the level of emotional burnout and empathic abilities by V.V.Boyko, emotional intelligence by D.V.Lyusin, the style of behavior self-regulation by
The criteria for ranking and prioritization of rehabilitation of abandoned mines
The rehabilitation of abandoned mines begins with the characterization and ranking of these mines.Based on this, countries, organizations, and individual researchers have developed tools for ranking abandoned mines for rehabilitation.This paper comments on the issues of abandoned mines which include their definition and the problems they possess.It